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p53 Codon 72 and MDM2 SNP309 Polymorphisms and Age of Colorectal Cancer Onset in Lynch Syndrome

โœ Scribed by Sotamaa, K.

Book ID
126716619
Publisher
American Association for Cancer Research
Year
2005
Tongue
English
Weight
155 KB
Volume
11
Category
Article
ISSN
1078-0432

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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a