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The polymorphisms of P53 codon 72 and MDM2 SNP309 and renal cell carcinoma risk in a low arsenic exposure area

โœ Scribed by Chao-Yuan Huang; Chien-Tien Su; Jan-Show Chu; Shu-Pin Huang; Yeong-Shiau Pu; Hsiu-Yuan Yang; Chi-Jung Chung; Chia-Chang Wu; Yu-Mei Hsueh

Book ID
113924939
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
208 KB
Volume
257
Category
Article
ISSN
0041-008X

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โœ Xiujuan Xiong; Min Wang; Lin Wang; Jiazhuo Liu; Xin Zhao; Zheng Tian; Jianxiang ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 160 KB

A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a