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Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer

✍ Scribed by Osamu NUNOBIKI; Masatsugu UEDA; Michiko YAMAMOTO; Eisaku TOJI; Naomi SATO; Shinji IZUMA; Yoshiaki OKAMOTO; Kiyo TORII; Sadamu NODA

Book ID
111390494
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
122 KB
Volume
22
Category
Article
ISSN
0914-7470

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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a