A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a
✦ LIBER ✦
Influence of MDM2 SNP309 alone or in combination with the TP53 R72P polymorphism in oligodendroglial tumors
✍ Scribed by Ahmed Idbaih; Blandine Boisselier; Yannick Marie; Marc Sanson; Soufiane El Hallani; Emmanuelle Crinière; Maryam Fourtassi; Sophie Paris; Catherine Carpentier; Audrey Rousseau; Karima Mokhtari; Christophe Combadière; Florence Laigle-Donadey; Khê Hoang-Xuan; Jean-Yves Delattre
- Book ID
- 113503311
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 232 KB
- Volume
- 1198
- Category
- Article
- ISSN
- 0006-8993
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