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Toward the synthesis of the antibiotic tetrodecamycin

✍ Scribed by Franz F Paintner; Gerd Bauschke; Marion Kestel

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 84 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01809-8

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✦ Synopsis

We report here a short approach to a tricyclic substructure of tetrodecamycin exhibiting a unique ring skeleton utilising an acid catalysed ring closure as the key step. In addition an efficient three-step synthesis of 5-alkylidene 4-methoxy-2(5H)-furanones starting from 4-methoxy-2(5H)-furanone is described.

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