Studies directed towards the total synthesis of the ionophore antibiotic A-23187

✍ Scribed by D.A. Evans; C.E. Sacks; R.A. Whitney; N.G. Mandel

• Publisher: Elsevier Science
• Year: 1978
• Tongue: French
• Weight: 246 KB
• Volume: 19
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)85378-8

✦ Synopsis

The carboxylic acid antibiotic A-23187 (A) is a divalent cation ionophore which has been isolated from cultures of Streptomyces chartreusensis.' The structure and proposed absolute configuration2 have shown it to be one of a limited group of natural products, including oligomycin B3 and aplysiatoxin, 4 which contains the unusual 1,7-dioxaspiro[5.5]undecane ring