A synthesis of the C9-C23 subunit of the group A streptogramin antibiotics is described. The synthesis incorporates a palladium-catalysed sp-sp coupling and a catalytic asymmetric vinylogous Mukaiyama aldol reaction to induce the stereogenic centre at C14.
Studies towards the synthesis of antitumor antibiotics of the anthramycin group
โ Scribed by Nicole Langlois; Florence Favre
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 244 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
We report here a short approach to a tricyclic substructure of tetrodecamycin exhibiting a unique ring skeleton utilising an acid catalysed ring closure as the key step. In addition an efficient three-step synthesis of 5-alkylidene 4-methoxy-2(5H)-furanones starting from 4-methoxy-2(5H)-furanone is
Diisopropylidine methylene dimalonate (g) has been developed as a useful reagent Kansas for the introduction of functionalized 3-carbon chains in otherwise deactivated monohydroxyanthraquinones and its utility is expanded to the synthesis of advanced intermediates of 11-deoxydoxorubicin analogues. T
The carboxylic acid antibiotic A-23187 (A) is a divalent cation ionophore which has been isolated from cultures of Streptomyces chartreusensis.' The structure and proposed absolute configuration2 have shown it to be one of a limited group of natural products, including oligomycin B3 and aplysiatoxin