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Total synthesis of prostaglandins. III. 11-desoxyprostaglandins.

✍ Scribed by Charles J. Sih; Robert G. Salomon; Philip Price; Rattan Sood; George Peruzzotti

Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
127 KB
Volume
13
Category
Article
ISSN
0040-4039

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✦ Synopsis

In addition to their interesting pharmacological properties, 2.3,4 the desoxyprostaglandins are also potentially important intermediates for conversion into the naturally occurring prostaglandins via microbiological hydroxylation. The recent report5 of an improved synthesis of an important intermediate to the lldesoxyprostaglandins prompts us to record our efficient preparation of this class of compounds.

The first total synthesis of a pharmacologically-active prostenoate was reported by Bagli and coworkers at Ayerst. 6 The prostenoate skeleton was elabo-

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For some time we have been engaged in a research program having 1 as its main objective the chemical synthesis of modified prostaglandins . Among the numerous total syntheses now available, one reported by the Harvard group 2 was of particular interest to us, because it is stereo-