In addition to their interesting pharmacological properties, 2.3,4 the desoxyprostaglandins are also potentially important intermediates for conversion into the naturally occurring prostaglandins via microbiological hydroxylation. The recent report5 of an improved synthesis of an important intermedi
Total synthesis of 11-nor prostaglandins
✍ Scribed by A.E. Greene; J.P. Deprès; M.C. Meana; P. Crabbé
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 215 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
For some time we have been engaged in a research program having 1 as its main objective the chemical synthesis of modified prostaglandins . Among the numerous total syntheses now available, one reported by the Harvard group 2 was of particular interest to us, because it is stereo-
We wish to report the synthesis of prostaglandin E2 (PGE2, &) via conjugate addition of the vinyl cupratez, derived from trans-3(E)-(l-ethoxyethoxy)l-iodo-l-octene (3b), to 2-(6-carbomethoxy-~-2-hexenyl)-4(R)-(2-tetrahydropyranyloxy)-2-cyclopenten-l-one (s). We also describe herein a novel synthesis