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Total synthesis of prostaglandin D2

✍ Scribed by Erwin F. Jenny; Peter Schäublin; Hans Fritz; Hermann Fuhrer


Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
188 KB
Volume
15
Category
Article
ISSN
0040-4039

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Total synthesis of prostaglandins. V. A
✍ J.B. Heather; Rattan Sood; Philip Price; George P. Peruzzotti; Sang.S. Lee; Hsu 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 225 KB

We wish to report the synthesis of prostaglandin E2 (PGE2, &) via conjugate addition of the vinyl cupratez, derived from trans-3(E)-(l-ethoxyethoxy)l-iodo-l-octene (3b), to 2-(6-carbomethoxy-~-2-hexenyl)-4(R)-(2-tetrahydropyranyloxy)-2-cyclopenten-l-one (s). We also describe herein a novel synthesis