As part of our program to synthesize compounds with potential antifertility properties, we have prepared certain lo-oxa-11-desoxy-prostaglandin analogs.2
Synthesis of 11-desoxy-prostaglandins
✍ Scribed by Pierre Crabbé; Angel Guzmán
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 154 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
For some time we have been engaged in a research program having 1 as its main objective the chemical synthesis of modified prostaglandins . Among the numerous total syntheses now available, one reported by the Harvard group 2 was of particular interest to us, because it is stereo-
📜 SIMILAR VOLUMES
De nombreuses approches a la synthese de prostaglandines ont &6 ddcrites. Cet important effort, qui est justifid si l'on considere l'intdret pharmacologique de ces substances, traduit aussi la difficult6 d'avoir une plaque tournante donnant un accbs court et simple & des produits B visde physiologiq
In addition to their interesting pharmacological properties, 2.3,4 the desoxyprostaglandins are also potentially important intermediates for conversion into the naturally occurring prostaglandins via microbiological hydroxylation. The recent report5 of an improved synthesis of an important intermedi