For some time we have been engaged in a research program having 1 as its main objective the chemical synthesis of modified prostaglandins . Among the numerous total syntheses now available, one reported by the Harvard group 2 was of particular interest to us, because it is stereo-
10-oxa-11-desoxy-prostaglandins
β Scribed by Frank M. Hauser; Ronald C. Huffman
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 167 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
As part of our program to synthesize compounds with potential antifertility properties, we have prepared certain lo-oxa-11-desoxy-prostaglandin analogs.2
π SIMILAR VOLUMES
De nombreuses approches a la synthese de prostaglandines ont &6 ddcrites. Cet important effort, qui est justifid si l'on considere l'intdret pharmacologique de ces substances, traduit aussi la difficult6 d'avoir une plaque tournante donnant un accbs court et simple & des produits B visde physiologiq
The oxaprostaglandin analog (la) , in which an oxygen heteroatom replaces a methylene group in the side chain of the natural substance (lb), has interesting biological properties.