In addition to their interesting pharmacological properties, 2.3,4 the desoxyprostaglandins are also potentially important intermediates for conversion into the naturally occurring prostaglandins via microbiological hydroxylation. The recent report5 of an improved synthesis of an important intermedi
Prostaglandin VI - an efficient synthesis of II-desoxyprostaglandins
β Scribed by N.A. Abraham
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 105 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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An asymmetric total synthesis of Prostaglandin E 1 (5) has with the Corey CBS catalyst gave the Ο-side chain 7 with ΟΎ96% ee. Conjugate addition using the reaction with been achieved in a two-component coupling process. The chiral hydroxycyclopentenone 6 was readily available from dilithiocyanocuprat
An expeditious and efftcient formal total synthesis of an antiviral and antitumor tetracyclic diterpene aphidicolin (1) has been achieved. An intramoleculat Heck reaction (74) and an intramolecular Diels-Aldex reaction (4+3) were utilii for the key steps of the sequence.