𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An Efficient Asymmetric Synthesis of Prostaglandin E1

✍ Scribed by Ana Rodríguez; Miguel Nomen; Bernd Werner Spur; Jean-Jacques Godfroid

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
364 KB
Volume
1999
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

An asymmetric total synthesis of Prostaglandin E 1 (5) has with the Corey CBS catalyst gave the ω-side chain 7 with Ͼ96% ee. Conjugate addition using the reaction with been achieved in a two-component coupling process. The chiral hydroxycyclopentenone 6 was readily available from dilithiocyanocuprate followed by mild cleavage of the silyl protective groups and enzymatic hydrolysis of the methyl furan with 96% ee. The key reaction step was a kinetic enzymatic resolution followed by an in situ inversion. A ester 22 gave (-)-PGE 1 5 in high yield. catalytic asymmetric reduction of the γ-iodo vinyl ketone 19 [a] Department of Cell Biology, University of Medicine and Denti-Ϫ100°C (88% ee), [14] CBS at room temperature (93% stry of New Jersey, SOM ee), [15] YamamotoЈs diisobutylaluminum-2,6-di-tert-butyl-

📜 SIMILAR VOLUMES

An Efficient Asymmetric Synthesis of Tar
An Efficient Asymmetric Synthesis of Tarchonanthuslactone.
✍ Dieter Enders; Daniel Steinbusch 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 155 KB 👁 2 views

2004 Other bioactive products ## Other bioactive products U 1300 An Efficient Asymmetric Synthesis of Tarchonanthuslactone. -Key steps of the new asymmetric synthesis of tarchonanthuslactone (X) are the enzymatic transformation of diketo ester (I) to lactone (II) in excellent stereoselectivity,

ChemInform Abstract: An Efficient Asymme
ChemInform Abstract: An Efficient Asymmetric Synthesis of Tarchonanthuslactone.
✍ M. Venkat Ram Reddy; Ahmet J. Yucel; P. Veeraraghavan Ramachandran 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v