The Pd-Cu coupling reaction of a chrral hydroxy-(E,E)-rododrene wrth a racemlc acetylenlc alcohol followed by reduction of the dlenyne leads to the desired (Z.E,E) geometry and allows synthesis of LTB4 and its S-eprmer after reparation of dlastereomers
β¦ LIBER β¦
Total synthesis of leukotriene B5
β Scribed by E.J. Corey; Stephen G. Pyne; Wei-guo Su
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 225 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
A practical, stereocontrolled synthesis of leukotriene B5 is described which makes this substance readily available for the first time.
Previous papers from this laboratory have described two total syntheses of leukotriene B4 (3
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