Leukotriene LTD4 analogs 20-OH LTD4 16 and ZO-COOH LTD4 17 were synthesized. These ti-oxidative derivatives are possible metΓ£601ites of the natural product. The leukotrienes LTC4, LTD4 and LTE4, also known as SRS-A (slow reacting substance of anaphalaxis) are al1 potent spasmogens, producing smooth
Total synthesis of 20-hydroxy- and 20-carboxy-leukotrienes B4
β Scribed by K.C Nicolaou; Y.S Chung; P.E Hernandez; I.M Taffer; R.E Zipkin
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 143 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
3(S)-Hydmxy-m B, (la), its 3(R)-epima lb, and a 14.15acetylenic endogue were effWently prepad vie cheletiakamtrolled reduaion of keme 12. obtained by acetylide addition te ehbal Ehydmxylacmes 7p. Leukotriene B4 (LTB,) is an important lipid mediator in inflammatory and immunologic responses.r In rec
The Pd-Cu coupling reaction of a chrral hydroxy-(E,E)-rododrene wrth a racemlc acetylenlc alcohol followed by reduction of the dlenyne leads to the desired (Z.E,E) geometry and allows synthesis of LTB4 and its S-eprmer after reparation of dlastereomers