A stereospecific and chorally economical synthesis of LTE, starting from E-deoxy-D-nbose IS reported as part of a comprehensive and efflclent approach to the Leukotnenes (A, 8, C, 0, E). The process includes a novel approach to choral dienlc synthons. Leukotnene 8, (1) IS a component of the arachldo
Synthesis of 19-hydroxy LTB4, an assumed metabolite of leukotriene B4
β Scribed by Yves Le Merrer; A. Bonnet; J.C. Depezay
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 268 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The first total synthesis of the methyl ester of 20-oxo-LTB 4 26 is described. The key synthon 6 is an advanced new intermediate which has been used in the synthesis of LTB 4 1, 20-oxo-LTB 4 methyl ester 26, and 20-hydroxy-LTB 4 2. The synthetic 26 has been used to study the cytosolic aldehyde dehyd
3(S)-Hydmxy-m B, (la), its 3(R)-epima lb, and a 14.15acetylenic endogue were effWently prepad vie cheletiakamtrolled reduaion of keme 12. obtained by acetylide addition te ehbal Ehydmxylacmes 7p. Leukotriene B4 (LTB,) is an important lipid mediator in inflammatory and immunologic responses.r In rec
The stereospecific synthesis of the recently identified metabolites of LT8 1: 5(S),lZ(R),20-trihydroxy-6-cis,8,10-trans,l4-cis-eicosatetraenoic acid 2 and 5(S),12!Rr,dihydroxy-6-cis,8,10-trans,l4-cis-eicosatetraen-l,20-dioic acid 3, via thz synthon 4 has been accomplished; identity of synthetic and