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Stereospecific synthesis of leukotriene B4 (LTB4)

✍ Scribed by Yvan Guindon; Robert Zamboni; Cheuk-Kun Lau; Joshua Rokach

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 253 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)86935-x

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✦ Synopsis

A stereospecific and chorally economical synthesis of LTE, starting from E-deoxy-D-nbose IS reported as part of a comprehensive and efflclent approach to the Leukotnenes (A, 8, C, 0, E). The process includes a novel approach to choral dienlc synthons. Leukotnene 8, (1) IS a component of the arachldonlc acid cascade which has been recently lsolatedl and characterized*. This local hormone stimulates leukocyte functlons3 (chemotaxls, chemokinesis), induces an increase in capillary permeablllty3 and causes smooth muscle contrac-tion4. The potential importance of LTE, in allergic and inflammatory states and the need for a better supply to lnvestlgate Its properties prompted us to embark on the synthesis of this mediator which we are now reporting. HO 1, LT84 1.

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