Total synthesis of the ethanol inducible, proinflammatory autacoid 3(S)-hydroxy-leukotriene B4 (3-OH-LTB4) and analogues

✍ Scribed by Kamlesh Chauhan; Rama K. Bhatt; J.R. Falck; Jorge H. Capdevila

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 295 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73170-4

✦ Synopsis

3(S)-Hydmxy-m B, (la), its 3(R)-epima lb, and a 14.15acetylenic endogue were effWently prepad vie cheletiakamtrolled reduaion of keme 12. obtained by acetylide addition te ehbal Ehydmxylacmes 7p.

Leukotriene B4 (LTB,) is an important lipid mediator in inflammatory and immunologic responses.r In recent years, considerable attention has been devoted to elucidating its metabolic fate;lespecially by catabolic