Althiomycin (1) is a naturally occurring antibiotic, active against both gram-positive and gram-negative bacteria, t~ Its mechanism of action involves inhibition of protein synthesis at the peptidyltransferase stage. 2"4 Ahhiomycin is selective for prokaryotic organisms and does not inhibit protein
Total synthesis of antibiotic althiomycin
โ Scribed by Kaoru Inami; Tetsuo Shiba
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 237 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Antibiotic althiomycin was totally synthesized from D-cysteine via the procedures of the coupling with sodium salt of pyrrolinone, hydroxymethylation, and the coupling with the thiazole part, successively.
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