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Total synthesis of peptide antibiotic nisin

✍ Scribed by Koichi Fukase; Manabu Kitazawa; Akihiko Sano; Kuniaki Shimbo; Hiroshi Fujita; Shingo Horimoto; Tateaki Wakamiya; Tetsuo Shiba

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 291 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80212-9

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✦ Synopsis

Sumnary: Total synthesis of a lanthionine peptide nisin was successfully achieved for the first time by application of new methods for preparations of dehydroalanine and lanthionine moieties, resulting in a confirmation of the proposed structure. A peptide antibiotic nisin has been used as a food preservative, since it shows a remarkable antibacterial activity particularly against Clostridium botulinum. Nisin was first found in 1928') but isolated by Mattick et al. in 1947 ) 2 from Streptococcus lactis -. Its unique

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