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Total synthesis of antibiotic karnamicin B1

✍ Scribed by Kazuyuki Umemura; Koichi Watanabe; Kazumasa Ono; Masanori Yamaura; Juji Yoshimura

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 177 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01039-3

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✦ Synopsis

The novel antifungal karnamicin B, (1), 5-hydroxy-3,4-dimethoxy-2-(2-(4-oxopentyl)-4-thiazolyl}pyridine-6-carboxamide was first synthesized via the formation of partially methylated trihydroxy pyridine by ring-transformation from the corresponding furan derivative and subsequent regioselective introduction of 2,6substituents using Meisenheimer-type reaction.

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