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A formal synthesis of althiomycin

โœ Scribed by Peter L Toogood; Jessica J Hollenbeck; Huong M Lam; Li Li

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
206 KB
Volume
6
Category
Article
ISSN
0960-894X

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โœฆ Synopsis

Althiomycin (1) is a naturally occurring antibiotic, active against both gram-positive and gram-negative bacteria, t~ Its mechanism of action involves inhibition of protein synthesis at the peptidyltransferase stage. 2"4 Ahhiomycin is selective for prokaryotic organisms and does not inhibit protein synthesis in rabbit retieulocyte lysates. The structure of althiomycin was determined through chemical analysis, degradation studies, and Xray diffraction, t'5 Biosynthetically, althiomycin appears to be derived from the pentapeptide H~-gly-cys-sercys-gly-OH by post-translational modification, although this pathway has not been proven. ~b The organization of these residues into the tricyclic structure of althiomycin gives the molecule an are-like structure in three-

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