Total synthesis of 5S, 12S-dihydroxy-6,10-E,8,14-Z-eicosatetraenoic acid (5S,12S-di-HETE) (2), a new human metabolite of arachidonic acid
โ Scribed by E.J. Corey; Anthony Marfat; Bennett C. Laguzza
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 194 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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Enantiospecific syntheses of the ZO-and both 19-hydroxy metabolites of 12(S)-HETE were accomplished using readily available, chiral precursors. Recently, a new metabolite of 12(S)-hydroxyeicosatetraenoic (12-HETE) acid (1) was isolated from the coincubation of human platelets and neutrophils with ar
An efficient and simple total synthesis of the two C(8) diastereomers of 2, of interest as possible hormonal releasing agents, is described. A previous publication from this laboratory has described the synthesis of the two diastereomeric lo-hydroxy-11, lZ(S, S)-epoxyeicosa-5,9,14(Z)-trienoic acids