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The stereospecific synthesis of 14S,15S-oxido 5Z,8Z,10E,12E-eicosatetraenoic acid

โœ Scribed by Robert Zamboni; Suzanne Milette; Joshua Rokach

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
209 KB
Volume
24
Category
Article
ISSN
0040-4039

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12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetra
12-Hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE) stimulates cAMP production in normal human fibroblasts
โœ Shoko Ueki; Junichi Takagi; Yuichi Kobayashi; Fumie Sato; Yuji Saito ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 150 KB

We report here that the 12-lipoxygenase metabolite of arachidonic acid, 12hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE), stimulates cAMP production in human fibroblasts among various cultured cell lines tested. Although 12-HETE seemed to stimulate the phospholipase C (PLC)-protein kinase