✦ LIBER ✦

Total synthesis of biologically active metabolites of arachidonic acid. The two 8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acids.

✍ Scribed by E.J. Corey; Wei-guo Su

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 229 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81539-2

No coin nor oath required. For personal study only.

✦ Synopsis

An efficient and simple total synthesis of the two C(8) diastereomers of 2, of interest as possible hormonal releasing agents, is described.

A previous publication from this laboratory has described the synthesis of the two diastereomeric lo-hydroxy-11, lZ(S, S)-epoxyeicosa-5,9,14(Z)-trienoic acids ( L) and their identity with two new metabo-

📜 SIMILAR VOLUMES

Total synthesis of 12-(S)-10-hydroxy-tra

Total synthesis of 12-(S)-10-hydroxy-trans-11,12-epoxyeicosa-5,9,14-(Z)-trienoic acids, metabolites of arachidonic acid in mammalian blood platelets

✍ E.J. Corey; Jahyo Kang; Bennett C. Laguzza; Robert L. Jones 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 207 KB

The two isomeric hydroxy-11,12-epoxides produced from arachidonic acid in mammalian blood platelets have been identified by comparison with totally synthetic substances as the C (lO)diastereomers of 2.

Total synthesis of 5(S),12(S)- and 5(S),

Total synthesis of 5(S),12(S)- and 5(S),12(R)-dihydroxyeicosa-6(Z),8(E),14(Z)-trienoic acids, metabolites of leukotriene B4

✍ Pendri Yadagiri; Sun Lumin; J.R Falck; Armando Karara; Jorge Capdevila 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 253 KB

Total synthesis of 5S, 12S-dihydroxy-6,1

Total synthesis of 5S, 12S-dihydroxy-6,10-E,8,14-Z-eicosatetraenoic acid (5S,12S-di-HETE) (2), a new human metabolite of arachidonic acid

✍ E.J. Corey; Anthony Marfat; Bennett C. Laguzza 📂 Article 📅 1981 🏛 Elsevier Science 🌐 French ⚖ 194 KB

A stereoselective synthesis of 8(R) and

A stereoselective synthesis of 8(R) and 8(S),11(R),12(S)-trihydroxyeicosa-5(Z),9(E),14(Z)-trienoic acid from 2-deoxy-D-ribose

✍ J.S. Yadav; Prahlad Vadapalli 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 260 KB

Asymmetric Synthesis of the Stereoisomer

Asymmetric Synthesis of the Stereoisomers of 11,12,15(S)-Trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic Acid, a Potent Endothelium-Derived Vasodilator.

✍ J. R. Falck; Deb K. Barma; Suchismita Mohapatra; A. Bandyopadhyay; Komandla Mall 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 203 KB 👁 1 views

ChemInform Abstract: The Total Synthesis

ChemInform Abstract: The Total Synthesis of 5-Oxo-12(S)-hydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic Acid and Its 8,9-trans-Isomer and Their Identification in Human Platelets.

✍ Subhash Khanapure; William S. Powell; Joshua Rokach 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views