𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tomatoes and risk of digestive-tract cancers

✍ Scribed by Silvia Franceschi; Ettore Bidoli; Carlo La Vecchia; Renato Talamini; Barbara D'Avanzo; Eva Negri

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
420 KB
Volume
59
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In view of the persisting uncertainty concerning possible mechanisms by which high vegetable and fruit intake decreases cancer risk, foods with divergent values for potentially important micronutrients are a priority for investigation. Tomatoes are low in beta‐carotene, but high in lycopene, an active antioxidative agent. In order to assess the effect of tomatoes on risk of cancers of the digestive tract, data were analyzed from an integrated series of case‐control studies conducted between 1985 and 1991 in northern Italy, where tomato intake is high but, also, heterogeneous. The overall dataset included the following histologically confirmed cancer cases: oral cavity and pharynx, 314; esophagus, 85; stomach, 723; colon, 955; and rectum, 629; and a total of 2,879 controls admitted to hospital for acute non‐neoplastic or non‐digestive conditions, unrelated to long‐term dietary modifications. Multivariate odds ratios (OR) and 95% confidence interval (CI) for subsequent quartiles of intake of raw tomatoes were derived, after allowance for age, sex, study center, education, smoking and drinking level, and tertile of total caloric intake. There was a consistent pattern of protection for all sites (OR in the upper quartile ranging between 0.4 and 0.7), most notably for gastrointestinal neoplasms. All trends in risk were highly significant. The beneficial effect of raw tomatoes in this population may be partly due to the fact that they constitute perhaps the most specific feature of the Mediterranean diet. However, if it is true that tomatoes protect against digestive‐tract cancers, this is of interest from both a scientific and a public health viewpoint.

📜 SIMILAR VOLUMES

Cancers of the digestive tract, alcohol
Cancers of the digestive tract, alcohol and tobacco
✍ A. J. Turns; G. Péqljignot; M. Gignoux; A Valla 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 288 KB

## Abstract In a systematic search for risks associated with the consumption of alcohol and tobacco in relation to cancers of the digestive tract, oesophageal cancer was found to be significantly related to both factors. There was a slightly elevated risk for rectal cancer among alcohol consumers a

Pipe smoking and cancers of the upper di
Pipe smoking and cancers of the upper digestive tract
✍ Giorgia Randi; Lorenza Scotti; Cristina Bosetti; Renato Talamini; Eva Negri; Fab 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 67 KB

## Abstract Pipe smoking has been related to the risk of cancers of the upper digestive and respiratory tract, but quantification of the risk for exclusive pipe smokers is still limited. To analyse the association between exclusive pipe smoking and cancers of the upper digestive tract, we used data

Methylation pattern of HLTF gene in dige
Methylation pattern of HLTF gene in digestive tract cancers
✍ Kenji Hibi; Hiroshi Nakayama; Yasuaki Kanyama; Yasuhiro Kodera; Katsuki Ito; Sei 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 237 KB

## Abstract Recently, the loss of helicase‐like transcription factor (HLTF) gene expression accompanied by HLTF promoter methylation was identified in colon cancers. We examined HLTF methylation in colorectal, gastric and esophageal carcinomas. Twenty‐five of 76 colorectal cancers (33%), 11 of 65 g

Alcohol drinking outside meals and cance
Alcohol drinking outside meals and cancers of the upper aero-digestive tract
✍ Luigino Dal Maso; Carlo La Vecchia; Jerry Polesel; Renato Talamini; Fabio Levi; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 65 KB

In our integrated series of case-control studies conducted in Italy and Switzerland (324 oral, 397 pharyngeal, 271 oesophageal, 506 laryngeal cancers and 3,263 controls), individuals who also drank alcoholic beverages outside meals showed an increased risk compared to those who drank at meals only.

Tobacco smoking and the risk of upper ae
Tobacco smoking and the risk of upper aero-digestive tract cancers: A reanalysis of case–control studies using spline models
✍ Jerry Polesel; Renato Talamini; Carlo La Vecchia; Fabio Levi; Luigi Barzan; Dieg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 182 KB 👁 1 views

## Abstract Although tobacco smoking has long been recognized as a major risk factor for cancer of the upper aero‐digestive tract (UADT, __i.e__., oral cavity, pharynx, larynx, and oesophagus), very few studies have provided estimates of the effect of very low tobacco consumption. Step‐functions ha