✦ LIBER ✦

Alcohol drinking outside meals and cancers of the upper aero-digestive tract

✍ Scribed by Luigino Dal Maso; Carlo La Vecchia; Jerry Polesel; Renato Talamini; Fabio Levi; Ettore Conti; Paola Zambon; Eva Negri; Silvia Franceschi

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 65 KB
Volume: 102
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.10723

No coin nor oath required. For personal study only.

✦ Synopsis

In our integrated series of case-control studies conducted in Italy and Switzerland (324 oral, 397 pharyngeal, 271 oesophageal, 506 laryngeal cancers and 3,263 controls), individuals who also drank alcoholic beverages outside meals showed an increased risk compared to those who drank at meals only. At any alcohol intake level, subjects also drinking between meals showed a more elevated risk of developing an upper aero-digestive tract cancer than subjects drinking only at meals. After adjustment for potential covariates, and, after allowance for the number of daily drinks to adjust for different alcohol-intake levels, the odds ratios for subjects reporting drinking outside meals were 1.5 (95% confidence interval [CI]: 1.0-2.2) for oral, 1.8 (95% CI: 1.3-2.5) for pharyngeal, 1.7 (95% CI: 1.2-2.5) for oesophageal and 1.2 (95% CI: 0.9-1.7) for laryngeal cancers. Our findings show that drinking pattern with respect to food consumption may influence alcohol carcinogenesis in the upper digestive and respiratory tract. An "alcohol washing effect" by chewing and swallowing is suggested.

📜 SIMILAR VOLUMES

Cancers of the digestive tract, alcohol

Cancers of the digestive tract, alcohol and tobacco

✍ A. J. Turns; G. Péqljignot; M. Gignoux; A Valla 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 288 KB

## Abstract In a systematic search for risks associated with the consumption of alcohol and tobacco in relation to cancers of the digestive tract, oesophageal cancer was found to be significantly related to both factors. There was a slightly elevated risk for rectal cancer among alcohol consumers a

Pipe smoking and cancers of the upper di

Pipe smoking and cancers of the upper digestive tract

✍ Giorgia Randi; Lorenza Scotti; Cristina Bosetti; Renato Talamini; Eva Negri; Fab 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 67 KB

## Abstract Pipe smoking has been related to the risk of cancers of the upper digestive and respiratory tract, but quantification of the risk for exclusive pipe smokers is still limited. To analyse the association between exclusive pipe smoking and cancers of the upper digestive tract, we used data

Association of polymorphisms in the cycl

Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract

✍ Shama Buch; Bing Zhu; Autumn Gaither Davis; Dominic Odom; Jill M. Siegfried; Jen 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB

## Abstract DNA repair enzyme genetic polymorphisms have been postulated to increase the risk of certain cancers in the presence of tobacco carcinogen exposures. The XPD protein is an important component of the TFIIH transcription factor complex. __XPD__ genetic polymorphisms resulting in amino aci

Tobacco smoking and the risk of upper ae

Tobacco smoking and the risk of upper aero-digestive tract cancers: A reanalysis of case–control studies using spline models

✍ Jerry Polesel; Renato Talamini; Carlo La Vecchia; Fabio Levi; Luigi Barzan; Dieg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 182 KB 👁 1 views

## Abstract Although tobacco smoking has long been recognized as a major risk factor for cancer of the upper aero‐digestive tract (UADT, __i.e__., oral cavity, pharynx, larynx, and oesophagus), very few studies have provided estimates of the effect of very low tobacco consumption. Step‐functions ha

Lifetime and baseline alcohol intake and

Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

✍ Cornelia Weikert; Thomas Dietrich; Heiner Boeing; Manuela M. Bergmann; Marie Chr 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 97 KB 👁 1 views

## Abstract Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero‐digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253

Analysis of the results of the micronucl

Analysis of the results of the micronucleus test in patients presenting upper digestive tract cancers and in non-cancerous subjects

✍ A. M. Mandard; F. Duigou; J. Marnay; Ph.-Masson; Qiu-Song-Lang; Yi-Jing-Shu; P. 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 338 KB 👁 1 views

A micronucleus test was performed on 75 subjects of whom 38 presented with cancer of the upper digestive tract and 37 were free of disease; the absence of cancerous or pre-cancerous lesions in this latter group was confirmed by endoscopy and vital staining. The daily levels of alcohol and tobacco co