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Methylation pattern of HLTF gene in digestive tract cancers

✍ Scribed by Kenji Hibi; Hiroshi Nakayama; Yasuaki Kanyama; Yasuhiro Kodera; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 237 KB
Volume: 104
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.10985

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✦ Synopsis

Abstract

Recently, the loss of helicase‐like transcription factor (HLTF) gene expression accompanied by HLTF promoter methylation was identified in colon cancers. We examined HLTF methylation in colorectal, gastric and esophageal carcinomas. Twenty‐five of 76 colorectal cancers (33%), 11 of 65 gastric cancers (17%), and 1 of 40 esophageal cancers (3%) demonstrated abnormal methylation of the HLTF promoter. Abnormal methylation was found in the tumors of patients at all clinical stages, suggesting that these cancers could be methylated from an early stage. These results suggested that HLTF might play a variety of roles depending on the tissue type and could be inactivated at an early stage in the tumorigenic pathway. © 2003 Wiley‐Liss, Inc.

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