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Thymidylate synthase gene polymorphism associated with response to methotrexate in ALL

Book ID
120863105
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2002
Weight
151 KB
Volume
1331
Category
Article
ISSN
1173-8324

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Polyglutamation of methotrexate with com
Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
✍ Thierry Dervieux; Daniel Furst; Diana Orentas Lein; Robert Capps; Katie Smith; M πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 197 KB πŸ‘ 2 views

## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (