The synthesis of a 30-thiocyanatocardenolide is described. The compound exhibited about 0.1 times the cardiotonic effect of digitoxigenin in the isolated frog heart preparation. A t a dosage of 20 mg/kg in the intact rat, it elicited ECG changes similar to those seen with a 10-mghg dose of digitoxig
Thiocardenolides II: Synthesis and pharmacological evaluation of 3β-thioacetyl-14β-hydroxy-5β-card-20 (22)-enolide
✍ Scribed by Hanley N. Abramson; Chian L. Huang; Chiu-Chung Ho; Lawrence L. Walny; You-Meei Hsu
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 270 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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