Synthesis of |21-14C|-3β-hydroxy-5β-pregnan-20-one and |21-14C|-5β-cholestan-3β-ol
✍ Scribed by H. M. Garraffo; M. E. Deluca; A. M. Seldes; E. G. Gros
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 205 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
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All solvents and reagents were purified and/or dried before using according to generally accepted procedures, unless otherwise stated. I4CH3I was purchased from New England Nucleor Corp. Prep. HPLC: Micromeritics liquid chromatograph, refractive-index detector. Anal. TLC: F254 TLC plates (Merck). Pr
The readily accessible pregna-5,16-dien-3/l-ol-20-one ( I ) was transformed into 3/l-acetoxy-pregna-5,I7-dien-20-isopropoxy-16one ( 9). This compound was labelled by base-catalyzed isotopic exchange and then reconverted into labelled pregna-5,16-dien-3/l-01-20-one (13). Hydrogenation of this last on