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Synthesis of 3β-Hydroxy[21-14C]-5β-pregn-8(14)-en-20-one from Chenodeoxycholic Acid

✍ Scribed by MóNica E. Deluca; Alicia M. Seldes; Eduardo G. Gros

Publisher
John Wiley and Sons
Year
1986
Tongue
German
Weight
496 KB
Volume
69
Category
Article
ISSN
0018-019X

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✦ Synopsis

All solvents and reagents were purified and/or dried before using according to generally accepted procedures, unless otherwise stated. I4CH3I was purchased from New England Nucleor Corp. Prep. HPLC: Micromeritics liquid chromatograph, refractive-index detector. Anal. TLC: F254 TLC plates (Merck). Prep.

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✍ B. M. Ranzi; F. Ronchetti; G. Russo 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 412 KB

The readily accessible pregna-5,16-dien-3/l-ol-20-one ( I ) was transformed into 3/l-acetoxy-pregna-5,I7-dien-20-isopropoxy-16one ( 9). This compound was labelled by base-catalyzed isotopic exchange and then reconverted into labelled pregna-5,16-dien-3/l-01-20-one (13). Hydrogenation of this last on