All solvents and reagents were purified and/or dried before using according to generally accepted procedures, unless otherwise stated. I4CH3I was purchased from New England Nucleor Corp. Prep. HPLC: Micromeritics liquid chromatograph, refractive-index detector. Anal. TLC: F254 TLC plates (Merck). Pr
Synthesis of PREGN-5-en-3β-o1-20-one-20-14C
✍ Scribed by A. M. Porto; E. G. Gros
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- French
- Weight
- 164 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The readily accessible pregna-5,16-dien-3/l-ol-20-one ( I ) was transformed into 3/l-acetoxy-pregna-5,I7-dien-20-isopropoxy-16one ( 9). This compound was labelled by base-catalyzed isotopic exchange and then reconverted into labelled pregna-5,16-dien-3/l-01-20-one (13). Hydrogenation of this last on
## Abstract (3__α__,5__α__)‐3‐Hydroxy‐__C__‐homopregnane‐11,20‐dione (**3**) was prepared in eleven steps from the commercially available pregn‐4‐ene‐3,11,20‐trione (**4**) __via__ the 11‐oxo‐13‐formyl‐12,13‐secopregnane intermediate **11** (__Scheme 2__). Subjection of this secopregnane to an intr