Thiocardenolides I: Synthesis and biological actions of 3β-thiocyanato-14β-hydroxy-5β-card-20(22)-enolide

✍ Scribed by Hanley N. Abramson; Chian L. Huang; Thomas F. Wu; Thomas Tobin

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 431 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650541

✦ Synopsis

The synthesis of a 30-thiocyanatocardenolide is described. The compound exhibited about 0.1 times the cardiotonic effect of digitoxigenin in the isolated frog heart preparation. A t a dosage of 20 mg/kg in the intact rat, it elicited ECG changes similar to those seen with a 10-mghg dose of digitoxigenin. Studies also revealed the new cardenolide to be a reversible inhibitor of so- dium-and potassium-activated adenosine triphosphatase.

Keyphrases

Thiocardenolides-3@-thiocyanato-l4@-hydroxy-5@-card-20(22)-enolide synthesized, screened for cardiotonic activity and effect on sodium-and potassium-activated adenosine triphosphatase Cardiotonic agents, potential-3@-thiocyanato-14@-hydroxy-5fl-card-20(22)-enolide synthesized and screened 0 Adenosine triphosphatase, sodium and potassium activated-effect of 3@-thiocyanato-l4@-hydroxy-5@-card-20(22)-enolide evaluated