Thio-analogues of 5,6-dihydrouridine
✍ Scribed by ?kari?, V.; Ga?bpert, B.; Hohnjec, M.
- Book ID
- 111656923
- Publisher
- The Royal Society of Chemistry
- Year
- 1970
- Tongue
- English
- Weight
- 544 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0022-4952
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📜 SIMILAR VOLUMES
## Abstract The hydrogenation of 2′, 3′‐__O__‐isopropylidene‐5‐methyluridine **(1)** in water over 5% Rh/Al~2~O~3~ gave (5 __R__)‐ and (5 __S__)‐5‐methyl‐5, 6‐dihydrouridine **(2)**, separated as 5′‐__O__‐(__p__‐tolylsulfonyl)‐ **(3)** and 5′‐__O__‐benzoyl‐ **(5)** derivatives by preparative TLC. o
## Amiprilose [ l,2-O-isopropylidene-3-O-(3-N,N-dimethylaminopropyl)-ce-D-glucofur- anose] (1) and its hydrochloride salt [Therafectin "~ (SM1213)] are synthetic carbohydrates [1,2] known to exhibit antiproliferative and anti-inflammatory activities [3][4][5][6]. Compound 1 acts as an immunomodula