## Abstract The hydrogenation of 2′, 3′‐__O__‐isopropylidene‐5‐methyluridine **(1)** in water over 5% Rh/Al~2~O~3~ gave (5 __R__)‐ and (5 __S__)‐5‐methyl‐5, 6‐dihydrouridine **(2)**, separated as 5′‐__O__‐(__p__‐tolylsulfonyl)‐ **(3)** and 5′‐__O__‐benzoyl‐ **(5)** derivatives by preparative TLC. o
Synthesis and chemistry of 5,6-dihydro-6-methoxyuridine derivatives. Access to O6,5′-cyclo-5,6-dihydrouridine
✍ Scribed by Jean-Louis Fourrey; Patrick Jouin
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 212 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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## Abstract Thermolysis of 5,6‐epimino‐5,6‐dihydro‐β‐ionone (**1**) and its __N__‐methyl derivative (**2**) leads to their monocyclic isomers **6** and **10**, respectively, presumably due to a direct [1,5]‐H shift; on prolonged heating, these isomers are converted easily into pyrrole derivatives.
On irradiation at -20", 5,6-epimino-5,6-dihydro-p-ionone (E)-3 rearranges to the products 6 and 7. The N-methyl derivative (E)-4 does not lead to any photoproduct upon brief irradiation; on prolonged irradiation, only unspecific photodecomposition is observed. The N-acylated derivative (E)-5 undergo
## Abstract __N__‐(2‐Amino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**9**) and __N__‐(2,4‐diamino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**6**) were synthesized from __N__‐(4‐oxocyclohexyl)acetamide (**5**) as novel peptidomimetic building blocks. With similar purpose, __N__‐(6‐oxo‐5,6,7,