Synthesis and molecular conformation of 2′,3′-O-isopropylidene-5′-deoxy-6(R),5′-cyclo-5,6-dihydrouridine
✍ Scribed by Yuriko Yamagata; Satoshi Fujii; Takaji Fujiwara; Ken-Ichi Tomita; Tohru Ueda
- Book ID
- 115747673
- Publisher
- Elsevier Science
- Year
- 1981
- Weight
- 427 KB
- Volume
- 654
- Category
- Article
- ISSN
- 0005-2787
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## Abstract The hydrogenation of 2′, 3′‐__O__‐isopropylidene‐5‐methyluridine **(1)** in water over 5% Rh/Al~2~O~3~ gave (5 __R__)‐ and (5 __S__)‐5‐methyl‐5, 6‐dihydrouridine **(2)**, separated as 5′‐__O__‐(__p__‐tolylsulfonyl)‐ **(3)** and 5′‐__O__‐benzoyl‐ **(5)** derivatives by preparative TLC. o
The structures of the title compounds (2b and 3) have been investigated in the solid state by X-ray methods. The crystals of 2b are monoclinic, space group P2,, and of 3 orthorhombit, space grtup P2,2,2,. The cell dimensions are: for 2b, a = 9.910(2), b = 11;745W, c = 11.810(3) A, /3 = 97.32(l)"; a