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Thin-section MR imaging of rat brain at 4.7 T

✍ Scribed by Yen-Ling Ting; Peter Bendel

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
811 KB
Volume
2
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

The brains of anesthetized 7‐month‐old male hooded rats were imaged in coronal, sagittal, and horizontal planes at 4.7 T. Images were obtained with a section thickness of 0.6 mm and in‐plane pixel size of 0.18‐0.20 mm, resulting in finer combined spatial and contrast resolution than in most previously published reports. This allowed detailed anatomic assignment of many brain structures on the basis of comparison with a histologic brain atlas. T1, apparent T2, and water proton density values of gray matter, white matter, and cerebrospinal fluid (CSF) were derived from saturation‐recovery and multiecho measurements. These values were used to calculate expected contrast‐to‐noise ratios as a function of TR and TE in spin‐echo imaging sequences. The optimal simultaneous contrast between gray and white matter and between CSF and gray matter was obtained on images with moderate T2 weighting, with a TR of 3.6 seconds and a TE of 45 msec. The use of thin sections was found to be essential for resolving many fine structures, and the improved sensitivity provided by the high magnetic field strength was crucial for imaging such thin sections at adequate signal‐to‐noise ratios.

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