## Abstract The brains of anesthetized 7‐month‐old male hooded rats were imaged in coronal, sagittal, and horizontal planes at 4.7 T. Images were obtained with a section thickness of 0.6 mm and in‐plane pixel size of 0.18‐0.20 mm, resulting in finer combined spatial and contrast resolution than in
MR imaging of normal rat brain at 0.35 T and correlated histology
✍ Scribed by Robert J. Fiel; James J. Alletto; Charles M. Severin; Peter A. Nickerson; Margaret A. Acara; Roberta J. Pentney
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 662 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A custom‐built small‐animal transceiver was used for in vivo imaging of normal rat brain at 0.35 T, with the objective of identifying anatomic components by comparison of images with corresponding histologic sections. The cerebrum, cerebellum, brain stem, ventricles, hippocampus, and subarachnoid space were identified and cerebrospinal fluid (CSF) was differentiated from gray matter and white matter on coronal and transaxial magnetic resonance (MR) images. These images compare favorably with those obtained by others at higher field strengths in regard to delineating major neuroanatomic structures. It is concluded that this technique will be useful for investigating smallanimal models of human neurologic disease involving morphologic and morphometric changes in gray matter, white matter, and CSF‐filled spaces.
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