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The visibility of the 1H NMR signal of ethanol in the dog brain

✍ Scribed by Leith N. Moxon; Stephen E. Rose; Luke J. Haseler; Graham J. Galloway; Ian M. Brereton; Peter Bore; David M. Doddrell

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
587 KB
Volume
19
Category
Article
ISSN
0740-3194

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✦ Synopsis

In vivo, high-resolution, volume-selected 1H NMR spectroscopy was used to monitor the concentration of ethanol in the dog brain following intravenous injection of ethanol. Equilibration of ethanol in the body water should result in approximately equivalent concentrations of ethanol in the blood and brain. However, the mean equilibrium brain ethanol concentration determined using N-acetylaspartate as an internal standard was only 23 +/- 5% of the blood ethanol concentration. The disparity between blood and brain ethanol concentrations was attributed to underestimation of the ethanol concentration due to overlapping resonances with NAA and to T2 attenuation or possible nondetection of the 1H signal from ethanol bound at the surface of cell membranes and partitioned into the hydrophobic core of membrane lipids.

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