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Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain

✍ Scribed by Rolf Gruetter; Douglas L. Rothman; Edward J. Novotny; Gerald I. Shulman; James W. Prichard; Robert G. Shulman

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
375 KB
Volume
27
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The difference between ^1^H NMR spectra obtained during eu‐ and hyperglycemia exhibited well‐resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent ^13^C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36‐ml volumes from the human brain every 3 min.

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