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Localized 1H NMR spectra of glutamate in the human brain

✍ Scribed by D. L. Rothman; C. C. Hanstock; O. A. C. Petroff; E. J. Novotny; J. W. Prichard; R. G. Shulman

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 718 KB
Volume: 25
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910250110

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✦ Synopsis

Abstract

Localized ^1^H NMR spectra at TE = 12 ms were obtained from cerebralcortex of human subjects using ISIS with surface suppression. The 2.29‐ppm resonance was assigned to C4 glutamate with contributions from C4 glutamine and GABA using in vivo spectral editing and comparison of chemical shift with pure compounds. The measured intensity ratio between the 2.29 resonance and the creatine resonance at 3.03 ppm was in good agreement with the ratio predicted from previously reported measurements of glutamate. glutamine, and GABA concentrations in biopsied human brain tissue.

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