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Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla

✍ Scribed by Rolf Gruetter; Michael Garwood; Kǎmil Uǧurbil; Elizabeth R. Seaquist

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
632 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Measurement of the resonances of glucose between 3.2 and 3.9 ppm in ^1^H NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites. The H1 resonance of α‐D‐glucose at 5.23 ppm is resolved from other metabolite peaks, but potentially overlaps with the intense water signal at 4.72 ppm. This paper demonstrates that the increased resolution at 4 Tesla permits to suppress the water signal sufficiently to reliably detect glucose directly at 5.23 ppm by ^1^H MRS and the estimated peak intensity is consistent with previous ^13^C NMR quantification.

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