𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Broadband decoupled, 1H-localized 13C MRS of the human brain at 4 tesla

✍ Scribed by Rolf Gruetter; Gregor Adriany; Hellmut Merkle; Peter M. Andersen

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
820 KB
Volume
36
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Broadband proton decoupling of the entire ^13^C spectrum was possible within power absorption guidelines and resulted in the detection of narrow (as low as 2–3 Hz), natural abundance signals from metabolites such as myo‐inositol, glutamate, N‐acetyl‐aspartate, and glutamine from 72 cm^3^ volumes in the human brain. To overcome the chemical shift displacement error, three‐dimensional localization on the ^1^H z magnetization was combined with polarization transfer. Efficiency of the heteronuclear localization method was demonstrated by the elimination of all scalp lipid resonances. A signal‐to‐noise ratio of 5:1 for 0.07 m__M__ [^13^C] was achieved in 12 min, which is approximately a fivefold improvement over the sensitivity reported at 2.1 Tesla.

📜 SIMILAR VOLUMES

Sensitivity-enhanced 13C MR spectroscopy
Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla
✍ D.W.J. Klomp; W.K.J. Renema; M. van der Graaf; B.E. de Galan; A.P.M. Kentgens; A 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 593 KB

## Abstract A new coil design for sensitivity‐enhanced ^13^C MR spectroscopy (MRS) of the human brain is presented. The design includes a quadrature transmit/receive head coil optimized for ^13^C MR sensitivity. Loss‐less blocking circuits inside the coil conductors allow this coil to be used insid

1H-localized broadband 13C NMR spectrosc
1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 T
✍ Pierre-Gilles Henry; Ivan Tkáč; Rolf Gruetter 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 715 KB

## Abstract Localized ^13^C NMR spectra were obtained from the rat brain in vivo over a broad spectral range (15–100 ppm) with minimal chemical‐shift displacement error (<10%) using semi‐adiabatic distortionless enhancement by polarization transfer (DEPT) combined with ^1^H localization. A new grad

Calibration of the 1H decoupling field s
Calibration of the 1H decoupling field strength and experimental evaluation of the specific RF absorption rate in 1H-decoupled human 13C-MRS
✍ Adrianus J. van den Bergh; Hendrikusy J. van den Boogert; Arend Heerschap 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 485 KB

For patient safety in human 1H decoupled 13C-MRS, it is absolutely necessary to evaluate the specific RF absorption rate (SAR) of the tissue exposed to 1H frequency irradiation. With the use of surface coils, the local SAR at the body surface is of most concern due to the inherent RF field inhomogen

Dynamic 13C−1H nuclear polarization of l
Dynamic 13C−1H nuclear polarization of lipid methylene resonances applied to broadband proton-decoupled in vivo13C MR spectroscopy of human breast and calf tissue
✍ Gabriele Ende; Peter Bachert 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 706 KB

## Abstract Dynamic nuclear polarization of the coupled ^13^C−^l^H spin system was studied for optimizing the signal‐to‐noise ratio of __in vivo__ ^13^C MR spectra. In particular, the truncated driven and transient nuclear Overhauser effect (NOE) of the proton‐decoupled ^13^C resonances from methyl

Observation of resolved glucose signals
Observation of resolved glucose signals in 1H NMR spectra of the human brain at 4 Tesla
✍ Rolf Gruetter; Michael Garwood; Kǎmil Uǧurbil; Elizabeth R. Seaquist 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 632 KB

## Abstract Measurement of the resonances of glucose between 3.2 and 3.9 ppm in ^1^H NMR spectra from the human brain is difficult due to spectral overlap with peaks from more concentrated metabolites. The H1 resonance of α‐D‐glucose at 5.23 ppm is resolved from other metabolite peaks, but potentia

In vivo detection of serine in the human
In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla
✍ Changho Choi; Ivan Dimitrov; Deborah Douglas; Chenguang Zhao; Halima Hawesa; Sub 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB 👁 1 views

## Abstract A single‐voxel proton magnetic resonance spectroscopy (^1^H‐MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (