Dynamic 13C−1H nuclear polarization of lipid methylene resonances applied to broadband proton-decoupled in vivo13C MR spectroscopy of human breast and calf tissue
✍ Scribed by Gabriele Ende; Peter Bachert
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 706 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Dynamic nuclear polarization of the coupled ^13^C−^l^H spin system was studied for optimizing the signal‐to‐noise ratio of in vivo ^13^C MR spectra. In particular, the truncated driven and transient nuclear Overhauser effect (NOE) of the proton‐decoupled ^13^C resonances from methylene carbons in vegetable oil and in human calf tissue was observed. Maximum in vivo NOE enhancements n = 1.5 and 0.9 were found, respectively. Theoretical fits to the data yield ^13^C−^1^ cross‐relaxation times in the order of 0.6 s. Significant signal enhancement over the whole in vivo ^13^C chemical shift range is obtained with minimum expense utilizing the NOE of the dipolar coupled ^13^C−^1^ spin system in addition to proton‐decoupling. NOE‐enhanced proton‐decoupled in vivo ^13^C MR spectra were acquired within 17 min in volunteer examinations from the human breast and the calf. These spectra show well‐resolved resonances of carbons in lipids and several other cellular compounds.