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The use of zinc enolates in the synthesis of a key intermediate for the preparation of trinem antibiotics

โœ Scribed by Gordon Kennedy; Tino Rossi; Bruno Tamburini


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
186 KB
Volume
37
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


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The Use of Zinc Enolates in the Synthesis of a Key Intermediate for the Preparation of Trinem Antibiotics. -The reaction of the azetidinone (I) with zinc enolates derived from a chiral methoxycyclohexanone provides the trinem antibiotic key intermediate (III) with good diastereoselectivity. -(KENNE

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Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int