The stereoselective synthesis of a protected 4-fonnyltrinem 8 was accomplished in good yield. This connpound is a I~tenlial intermediate in the synthesis of a wide range of 4-alkyl and alkenyl substituted trineua antibiotics, as evidenced by its reaction with a series of phosphoranes and phosphonatc
The stereoselective synthesis of a key intermediate of the trinem antibiotic sanfetrinem
β Scribed by Chiara Ghiron; Elisabetta Piga; Tino Rossi; Bruno Tamburini; Russell J. Thomas
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 203 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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The Stereoselective Synthesis of 4-Formyltrinem, a Key Intermediate for Novel Trinems. -Title compound (VIII) is a key intermediate for the preparation of a wide range of trinem derivatives. This is demonstrated by performing some Wittig reactions.
A new route to the enantiomerically pure azetidin-2-one 3, a key intermediate for the synthesis of trinems, has been developed, incorporating enantioselective intramolecular C-H insertion of ct-methoxycarbonyl-ot-diazoacetamide catalyzed by chiral Rh(II) complexes and diastereoselective arene hydrog
The Use of Zinc Enolates in the Synthesis of a Key Intermediate for the Preparation of Trinem Antibiotics. -The reaction of the azetidinone (I) with zinc enolates derived from a chiral methoxycyclohexanone provides the trinem antibiotic key intermediate (III) with good diastereoselectivity. -(KENNE
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