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The stereoselective synthesis of 4-formyltrinem, a key intermediate for novel trinems

✍ Scribed by Chiara Ghiron; Tino Rossi; Russell J. Thomas

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 209 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00665-5

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✦ Synopsis

The stereoselective synthesis of a protected 4-fonnyltrinem 8 was accomplished in good yield. This connpound is a I~tenlial intermediate in the synthesis of a wide range of 4-alkyl and alkenyl substituted trineua antibiotics, as evidenced by its reaction with a series of phosphoranes and phosphonatcs.

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