The stereoselective synthesis of a protected 4-fonnyltrinem 8 was accomplished in good yield. This connpound is a I~tenlial intermediate in the synthesis of a wide range of 4-alkyl and alkenyl substituted trineua antibiotics, as evidenced by its reaction with a series of phosphoranes and phosphonatc
A novel stereoselective synthesis of a chiral key intermediate for the preparation of vitamin D3
β Scribed by Susumi Hatakeyama; Hirotoshi Numata; Seiichi Takano
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 220 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Tosylate 1, which features the vitamin D triene unit, was stereoselectively synthesized from commercially available starting materials. This key intermediate undergoes a very efficient one-pot, two-step reaction with tetrabutyl ammonium fluoride to afford vitamin D analogue 2, which bears a cyclic s
The Stereoselective Synthesis of 4-Formyltrinem, a Key Intermediate for Novel Trinems. -Title compound (VIII) is a key intermediate for the preparation of a wide range of trinem derivatives. This is demonstrated by performing some Wittig reactions.
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